Your guide to health and prenatal genetics
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Assess your personalised prenatal risks, choose screening tests, and find nearby maternity clinics


The sensitivity and specificity estimates of particular NIPT tests, prevalence estimates are based on a meta-analysis and other studies, which incorporates clinical validation data, as well as the most recent data provided by NIPT manufacturers (on their respective websites or printed information materials). MyAdvisor tool should be used with caution for the comparison of different tests, because used data sets may vary by study design, sample size, analysis and other variables.


California Department of Health Services. Midtrimester Risk for Chromosome Abnormalities by Maternal Age at Term Chart. Accessed 20/10/2015

Gil MM, Quezada MS, Revello R, Akolekar R, Nicolaides KH. Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol. 2015 Mar;45(3):249-66. [PMID: 25639627

Grace MR, Hardisty E, Green NS, Davidson E, Stuebe AM, Vora NL. Cell free DNA testing-interpretation of results using an online calculator. Am J Obstet Gynecol. 2015 Jul;213(1):30-2. [PMID:25957020]

Hook EB. Rates of chromosome abnormalities at different maternal ages. Obstet Gynecol. 1981, 58(3); 282-5 [PMID: 6455611]

Morris JK, Mutton DE, Alberman E. Revised estimates of the maternal age specific live birth prevalence of Down's syndrome (modified). J Med Screen. 2002;9(1):2-6. [PMID: 11943789]

Snijders RJ, Sebire NJ, Nicolaides KH. Maternal age and gestational age-specific risk for chromosomal defects. Fetal Diagn Ther. 1995;10:356–67 [PMID: 8579773]

Snijders RJ, Sundberg K, Holzgreve W, Henry G, Nicolaides KH. Maternal age- and gestation-specific risk for trisomy 21. Ultrasound Obstet Gynecol. 1999 Mar;13(3): 167-701 [PMID: 10204206]

Zhang H, Gao Y, Jiang F, Fu M, Yuan Y, Guo Y, Zhu Z, Lin M, Liu Q, Tian Z, Zhang H, Chen F, Lau TK, Zhao L, Yi X, Yin Y, Wang W. Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies. Ultrasound Obstet Gynecol. 2015 May;45(5):530-8. [PMID: 25598039]

Wellesley D, Dolk H, Boyd PA, Greenlees R, Haeusler M, Nelen V, Garne E, Khoshnood B, Doray B, Rissmann A, Mullaney C, Calzolari E, Bakker M, Salvador J, Addor MC, Draper E, Rankin J, Tucker D. Rare Chromosome Abnormalities, Prevalence and Prenatal Diagnosis Rates from Population-based Congenital Anomaly Registers in Europe. Eur J Hum Genet. 2012 May;20(5):521-6 [PMID: 22234154]

Harmony Prenatal Test. Ariosa Diagnostics. Available at: Accessed Oct. 19, 2015.

IONA test. Premaitha Health. Available at Accessed Oct 20, 2015.

MaterniT21 PLUS. Sequenom. Available at: Accessed Oct. 19, 2015. Accessed Oct. 20, 2015

Panorama Prenatal Screen. Natera, Inc. Available at: Accessed Oct. 19, 2015.